BRCA2 c.8827C > T pathogenic mutation in a consanguineous Chinese family with hereditary breast cancer

ConclusionIn this study, we identified aBRCA2 c.8827C>T nonsense mutation with a truncated BRCA2 protein in a consanguineous Chinese Han family, suggesting individuals with this mutation should be regularly screened for malignancies such as breast, prostate, and ovarian cancer. Our study verified the function of thisBRCA2 mutation site and provided a new target for the precise treatment of such patients.
Source: Molecular Genetics & Genomic Medicine - Category: Genetics & Stem Cells Authors: Tags: ORIGINAL ARTICLE Source Type: research