Exhaled volatile organic compounds analysis by e-nose can detect idiopathic pulmonary fibrosis
The current diagnostic work-up and monitoring of idiopathic pulmonary fibrosis (IPF) is often
invasive and time consuming. Breath analysis by e-nose technology has shown potential in the
diagnosis of numerous respiratory diseases. In this pilot study, we investigated whether exhaled
breath analysis by an e-nose could discriminate among patients with IPF, healthy controls and COPD.
Second, we verified whether these classification could be repeated in a set of newly recruited
patients as external validation. Third, we evaluated any significant relationships between exhaled
VOCs and Bronchoalveolar lavage fluid (BALF) in IPF patients. We enrolled 32 patients with
well-characterized IPF, 33 individuals with COPD and 36 healthy controls. An electronic nose
(Cyranose 320) was used to analyze exhaled breath samples. Raw data were processed by Principal
component reduction and linear discriminant analysis. External validation in newly recruited
patients (10 IPF, 10 COPD and 10 controls)...
Source: Journal of Breath Research - Category: Respiratory Medicine Authors: Silvano Dragonieri, Giulia Scioscia, Vitaliano Nicola Quaranta, Pierluigi Carratu, Maria Pia Venuti, Michele Falcone, Giovanna Elisiana Carpagnano, Maria Pia Foschino Barbaro, Onofrio Resta and Donato Lacedonia Source Type: research