Interaction of Ethanol and Oral ANS-6637, a Selective ALDH2 Inhibitor in Males: A Randomized, Double-Blind, Placebo-Controlled, Single-Ascending Dose Cohort Study.

CONCLUSIONS: A single oral dose of ANS-6637 with up to 5 standards drinks over 2.5 hrs was generally well tolerated in healthy males. The most common pharmacological response was flushing and an increase in HR, which are known effects of acetaldehyde accumulation and consistent with inhibition of ADLH2 with oral ANS-6637 in combination with alcohol. The results of this alcohol interaction study support further testing of ANS-6637 in individuals with substance use disorders who may consume alcohol. PMID: 32687612 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/32687612?dopt=Abstract

Source: Alcoholism, Clinical and Experimental Research - July 19, 2020 Category: Addiction Authors: O'Malley SS, Shram MJ, Levy-Cooperman N, Vince B, Strumph PM, Diamond I, Blackburn BK Tags: Alcohol Clin Exp Res Source Type: research