Novel immune biomarkers in complex regional pain syndrome

We investigated serum levels of 29 cytokines and immune-activated kynurenine and tetrahydrobiopterin pathway metabolites in 15 complex regional pain syndrome (CRPS) subjects and 14 healthy controls. Significant reductions in interleukin-37 and tryptophan were found in CRPS subjects, along with positive correlations between kynurenine/tryptophan ratio and TNF- α levels with kinesiophobia, tetrahydrobiopterin levels with McGill pain score, sRAGE, and xanthurenic acid and neopterin levels with depression, anxiety and stress scores.

Source: Journal of Neuroimmunology - July 20, 2020 Category: Allergy & Immunology Authors: Marc Russo, Peter Georgius, Ananda Staats Pires, Benjamin Heng, Michael Allwright, Boris Guennewig, Danielle Santarelli, Dominic Bailey, Nathan T. Fiore, Vanessa Xiuwen Tan, Alexandra Latini, Gilles J. Guillemin, Paul J. Austin Source Type: research