GSE154736 CTCF ChIP-seq in OCM1 cells

Contributor : Peiwei ChaiSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensWe identified aberrant CTCF binding lead to a 3D chromosomal interactional driver in NTS locus that accelerates tumorigenesis of uveal melanoma. Both enhancer deletion and abolishing CTCF binding lead to the loss of chromosomal looping and triggered therapeutic efficacy in inhibiting tumorigenesis. Our study shed light on a functional chromosomal architecture induced enhancer hijacking, thereby provide novel concept of 3D-chromosomal conformation exploration.

http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE154736

Source: GEO: Gene Expression Omnibus - July 21, 2020 Category: Genetics & Stem Cells Tags: Genome binding/occupancy profiling by high throughput sequencing Homo sapiens Source Type: research