ANO1 in urethral SMCs contributes to sex differences in urethral spontaneous tone.

ANO1 in urethral SMCs contributes to sex differences in urethral spontaneous tone. Am J Physiol Renal Physiol. 2020 Jul 20;: Authors: Chen D, Meng W, Shu L, Liu S, Gu Y, Wang X, Feng M Abstract Stress urinary incontinence (SUI) is more common in women than in men, and gender differences in anatomical structure and physiology have been suggested; however, the cellular and molecular mechanisms involved remain unclear. Spontaneous tone of urethra was proved to take the fundamental effect in preventing occurrence of SUI. We investigated whether the urethral spontaneous tone exhibited gender differences. Here, we isolated the urethral smooth muscle and detected the spontaneous tones in female mouse and women. No spontaneous tone was found in male mouse and men. Furthermore, caffeine excited more contraction and [Ca2+]i in urethrae from female mouse than male mouse. Moreover, The ANO1 expression of single USM cells from women and female mouse are almost double those from men and male mouse. In summary, ANO1of urethral smooth muscle contributes to sex differences in urethral spontaneous tone. This finding may provide a new angle for treatment of SUI between women and men. PMID: 32686521 [PubMed - as supplied by publisher]
Source: American Journal of Physiology. Renal Physiology - Category: Physiology Authors: Tags: Am J Physiol Renal Physiol Source Type: research