Low-dose methadone for refractory chronic migraine accompanied by medication-overuse headache: a prospective cohort study

ConclusionLDM could represent a valuable and effective option in selected patients affected by RCM with continuous headache and MOH, although the frequency of early ADRs poses major safety concerns. Randomized controlled trials are needed to confirm the efficacy and safety of LDM prophylaxis.
Source: Neurological Sciences - Category: Neurology Source Type: research