Pathophysiology of neratinib-induced diarrhea in male and female rats: microbial alterations a potential determinant.

CONCLUSIONS: A reproducible diarrhea model was developed in both female and male rats, which indicated that diarrhea pathogenesis is multifactorial, including anatomical disruption particularly evident in the distal ileum, and alterations in microbial composition. PMID: 32683606 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/32683606?dopt=Abstract

Source: Breast Cancer - July 17, 2020 Category: Cancer & Oncology Authors: Secombe KR, Ball IA, Shirren J, Wignall AD, Keefe DM, Bowen JM Tags: Breast Cancer Source Type: research