Repolarization of tumor infiltrating macrophages and increased survival in mouse primary CNS lymphomas after XPO1 and BTK inhibition

ConclusionsThese data highlight the pathogenic role of the innate immune microenvironment in PCNSL and provide pre-clinical evidence for the development of selinexor and ibrutinib as a new promising therapeutic option with cytotoxic and immunomodulatory potential.

http://link.springer.com/10.1007/s11060-020-03580-y

Source: Journal of Neuro-Oncology - July 19, 2020 Category: Cancer & Oncology Source Type: research