Relationship Between Chronic Kidney Disease, Glucose Homeostasis, and Plasma Osteocalcin Carboxylation and Fragmentation

Chronic kidney disease (CKD) is associated with reduced insulin sensitivity, through mechanisms that are not well understood. Low vitamin K intake and incomplete carboxylation of the vitamin K-dependent protein osteocalcin may promote insulin resistance. We assessed relationships of osteocalcin concentration, carboxylation, and fragmentation with CKD and glucose homeostasis in a cross-sectional study.

Source: Journal of Renal Nutrition - July 17, 2020 Category: Urology & Nephrology Authors: Mario Kratz, Leila R. Zelnick, Olgica Trenchevska, Joshua W. Jeffs, Chad R. Borges, Hsin-Hui Tseng, Sarah L. Booth, Bryan R. Kestenbaum, Kristina M. Utzschneider, Ian H. de Boer Tags: Original Research Source Type: research