Differential diagnosis of aggressive neoplasms with plasmablastic and late post-follicular differentiation

Plasmablastic lymphoma (PBL) is a clinicopathological entity with a spectrum of epidemiological, clinical, morphological, phenotypic and genetic features. However, plasmablastic features (PB/F) also define other B-cell neoplasms including ALK positive large B-cell lymphoma, primary effusion lymphoma, HHV8 positive diffuse large B-cell lymphoma and plasmablastic myeloma, which, respectively, also have other characteristic clinical, and pathological determinants. In addition, late post follicular B-cell differentiation with partial plasma cell phenotypes can be variably encountered in EBV associated B-cell lymphomas and diffuse large B-cell lymphoma NOS, bringing them within differential diagnosis with the entities characterized by PB/F.

Source: Diagnostic Histopathology - July 17, 2020 Category: Pathology Authors: Gareth Leopold, Snjezana Dotlic, Ali Mahdi, Matthew Pugh, Stefan Dojcinov Tags: Mini-symposium: Lymphoreticular pathology Source Type: research