Catheter ablation of atrial fibrillation in overweight and obese patients: Where do we stand?

In this issue of International Journal of Cardiology, Weinmann et al. investigated the impact of overweight and obesity in 600 patients who underwent cryoballoon pulmonary vein (PV) isolation for atrial fibrillation (AF) on procedural characteristics and clinical outcomes [1]. Compared to patients that classified as normal, obese patients suffered more frequently from hypertension, diabetes mellitus, obstructive sleep apnea, and exhibited larger left atrial dimensions. No significant differences were found in complication rates between normal weight patients and overweight or obese patients.
Source: International Journal of Cardiology - Category: Cardiology Authors: Tags: Editorial Source Type: research

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Authors: Bergland OU, Søraas CL, Larstorp ACK, Halvorsen LV, Hjørnholm U, Hoffman P, Høieggen A, Fadl Elmula FEM Abstract PURPOSE: The blood pressure (BP) lowering effect of renal sympathetic denervation (RDN) in treatment-resistant hypertension shows variation amongst the existing randomised studies. The long-term efficacy and safety of RDN require further investigation. For the first time, we report BP changes and safety up to 7 years after RDN, compared to drug adjustment in the randomised Oslo RDN study. MATERIALS AND METHODS: Patients with treatment-resistant hypertension, defined...
Source: Blood Pressure - Category: Hematology Tags: Blood Press Source Type: research
Authors: Zhang W, Xu JZ, Lu XH, Li H, Wang D, Wang JG Abstract PURPOSE: We hypothesise that dietary sodium intake interacts with serum uric acid to influence blood pressure (BP) in children and adolescents. In the present study, we investigated ambulatory BP in relation to hyperuricaemia, dietary sodium intake and their interaction in children and adolescents with hypertension. MATERIALS AND METHODS:  A total of 616 study participants were 10-24 years old and had primary hypertension diagnosed after admission in a specialised inpatient ward. Ambulatory BP monitoring was performed during hospitalisat...
Source: Blood Pressure - Category: Hematology Tags: Blood Press Source Type: research
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Source: New Zealand Medical Journal - Category: General Medicine Tags: N Z Med J Source Type: research
Authors: Siamashvili M, Davis S Abstract INTRODUCTION: Bromocriptine mesylate quick release (QR) is a dopamine D2 receptor agonist and is the only oral, primarily centrally acting drug that can be used for the treatment of adults with type 2 diabetes. AREAS COVERED: The authors describe current recommendations on the use of bromocriptine mesylate QR. Major efficacy and safety parameters of the late phase trials, including The Cycloset Safety Trial, have been identified and presented. EXPERT OPINION: Efficacy of bromocriptine mesylate QR monotherapy appears to be low but is compensated by favorable safety pr...
Source: Expert Opinion on Pharmacotherapy - Category: Drugs & Pharmacology Tags: Expert Opin Pharmacother Source Type: research
We describe the various pharmacological and non-pharmacological strategies for AF management with a peek at some futuristic approaches. While each one of these variables could lend themselves for a separate review, we attempted to provide an overview of the most critical predictors of AF outcomes to equip the readers with the latest know-how of the management of AF.
Source: Current Cardiovascular Risk Reports - Category: Cardiology Source Type: research
Purpose of review Atrial fibrillation is the most common sustained cardiac arrhythmia, attributable to several factors that may be amenable through lifestyle modification. There is emerging evidence to suggest that the successful management of several cardiovascular risk factors [obesity, hypertension (HTN), diabetes mellitus, and obstructive sleep apnea (OSA)] can lead to fewer complications and atrial fibrillation prevention. However, the long-term sustainability and reproducibility of these effects have yet to be explored in larger studies. This review explores recent findings for exercise and lifestyle modifications ...
Source: Current Opinion in Cardiology - Category: Cardiology Tags: ARRHYTHMIAS: Edited by David Birnie Source Type: research
Abstract Atrial fibrillation (AF) is the most common clinical arrhythmia with a global burden that has increased progressively, contributing to rising hospitalizations and substantial healthcare demands(1-3). Although aging is an important contributor to the rising AF prevalence, key mechanistic promoters of AF include modifiable risk factors such as obesity, hypertension, diabetes mellitus and obstructive sleep apnea. Exercise training and physical activity improves the management of hypertension and diabetes(4), assists in weight management(5) and improves cardiac structure and function(6). Surprisingly, despite...
Source: Circulation - Category: Cardiology Authors: Tags: Circulation Source Type: research
Obesity is always associated with an increased risk of atrial fibrillation (AF), one of the most common atrial arrhythmias [1]. Besides, obesity and its associated numerous comorbidities, such as hypertension, hyperlipemia, diabetes mellitus and obstructive sleep apnea have been proposed to increase the prevalence and incidence of AF [2]. Munger TM et al. indicated that obesity is associated with structural and electrical remodeling of the atria that forms the substrate in the development and progression of AF [3].
Source: International Journal of Cardiology - Category: Cardiology Authors: Source Type: research
The incidence and prevalence of atrial fibrillation (AF) are increasing globally, and the arrhythmia has profound impact on patient outcomes (1). The precise reasons for the rising AF epidemic are unclear, and proposed causes include the aging population and increased incidence of risk factors such as hypertension and obesity. Data showing the link between cardiometabolic risk factors and AF are accumulating (2–6). The growing epidemic of obesity could be at the crux of many of these risk factors, including hypertension, diabetes mellitus, and obstructive sleep apnea (OSA). Evidence for a causative or contributo...
Source: Journal of the American College of Cardiology - Category: Cardiology Source Type: research
Abstract Obesity is a worldwide health problem with epidemic proportions that has been associated with atrial fibrillation (AF). Even though the underlying pathophysiological mechanisms have not been completely elucidated, several experimental and clinical studies implicate obesity in the initiation and perpetuation of AF. Of note, hypertension, diabetes mellitus, metabolic syndrome, coronary artery disease, and obstructive sleep apnea, represent clinical correlates between obesity and AF. In addition, ventricular adaptation, diastolic dysfunction, and epicardial adipose tissue appear to be implicated in atrial el...
Source: Journal of Cardiology - Category: Cardiology Authors: Tags: J Cardiol Source Type: research
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