CYP2C9 ( *2 & amp;*3 ) and CYP2C19 ( *2 & amp;*3 ) polymorphisms among children with nonlesional epilepsy: a single-center study

AbstractCytochrome (CYP) P450 enzymes are responsible for metabolism of antiepileptic drugs (AEDs), and encoded by highly polymorphic genes. A case –control study was conducted in Mansoura University Children’s Hospital, Egypt including 100 children with nonlesional epilepsy (50 AEDs responders and 50 resistant cases) and 50 healthy controls. All participants were investigated for frequencies ofCYP2C9 (*2&*3) andCYP2C19 (*2&*3) genotypes and alleles using polymerase chain reaction. The current study reported higher frequencies ofCYP2C9*2 (CT) genotype and (T) allele among responsive and resistant groups than controls (P  <  0.001). Frequency of (TT) genotype was higher in resistant than responsive group (P  =  0.02, OR 12, 95% CI 1.2–122.3). No significant differences were detected between responsive and resistant groups regardingCYP2C9*2 alleles (P  =  0.2).CYP2C9*3 (AC) genotype was more frequent in controls than other groups (P  <  0.001). No significant differences were detected between responsive and resistant groups regarding neitherCYP2C9*3 genotypes nor alleles (P  =  0.11 and 0.2, respectively).CYP2C19*2&*3 (GA) genotypes and (A) alleles were more frequent in responsive and resistant groups than controls (P  <  0.001). No significant differences were detected between responsive and resistant groups regarding neitherCYP2C19*2&*3 genotypes nor alleles (P  =  0.21 and 0.89 forCYP2C19*2;P  =  1 and 0.77 forCY...
Source: Acta Neurologica Belgica - Category: Neurology Source Type: research