Overexpression of lncRNA HULC Attenuates Myocardial Ischemia/reperfusion Injury in Rat Models and Apoptosis of Hypoxia/reoxygenation Cardiomyocytes via Targeting miR-377-5p through NLRP3/Caspase ‑1/IL‑1β Signaling Pathway Inhibition.

CONCLUSIONS: Overall, these results indicate that the protective effect of HULC against myocardial I/R injury and H/R cardiomyocyte apoptosis partially relies on the inhibition of NLRP3/Caspase‑1/IL‑1β signaling pathway. PMID: 32674625 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/32674625?dopt=Abstract

Source: Immunological Investigations - July 18, 2020 Category: Allergy & Immunology Tags: Immunol Invest Source Type: research