Decarboxylative Bromination of Heteroarenes: Initial Mechanistic Insights

Synlett DOI: 10.1055/s-0040-1707901 After an initial report from our laboratory describing metal-free decarboxylative halogenation of various azaheteroarenes, we set out to investigate the possible mechanism by which this chemistry occurs. Evidence from this mechanistic investigation suggests that this chemistry occurs via a radical pathway, with 1H NMR studies suggesting that the acidic substrates activate NBS. [...] © Georg Thieme Verlag Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text

Source: Synlett - July 16, 2020 Category: Chemistry Authors: Patel, Pritesh R. Henderson, Scott H. Roe, Mark S. Honey, Mark A. Tags: letter Source Type: research