Pantoprazole, a proton ‐pump inhibitor, impairs human sperm motility and capacitation in vitro

ConclusionOur results indicate that exposure to pantoprazole has an adverse effect on the physiological competence of human spermatozoa. As the capacitation process takes place within the female tract, our results suggest that PPIs intake by the female partner may impair in vivo sperm maturation and possibly fertilization. Moreover, the absence of adverse effect by PPIs on mouse sperm emphasizes the need to develop reprotox assays using human material to better assess the effects of medication intake on sperm physiology.

Source: Andrology - July 15, 2020 Category: Urology & Nephrology Authors: Jessica Escoffier, Bastien Arnaud, Mayis Kaba, Jean Pascal Hograindleur, Emilie Le Bl évec, Guillaume Martinez, Isabelle Stévant, Pierre F. Ray, Christophe Arnoult, Serge Nef Tags: ORIGINAL ARTICLE Source Type: research