Methylphenidate and mortality in children with attention-deficit hyperactivity disorder: population-based cohort study - Chen VCH, Chan HL, Wu SI, Lu ML, Dewey ME, Stewart R, Lee CTC.

BACKGROUND: Little is known about methylphenidate (MPH) use and mortality outcomes. AIMS: To investigate the association between MPH use and mortality among children with an attention-deficit hyperactivity disorder (ADHD) diagnosis. METHOD: This po...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news

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Discussion: MCI and ADHD in older individuals are dissociated clinical entities with overlapping cognitive profiles. Clinicians ought to be aware of these converging phenotypes to avoid misdiagnosis.
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
In this study, we performed biochemical assays, cell-based approaches, quantitative fluorescence analysis and functional studies that allowed us to demonstrate that p35KO mice exhibit decreased DA uptake and reduced cell surface DAT expression levels in the striatum (STR). These findings are supported by in vitro observations in which the inhibition of Cdk5 activity in N2a cells induced a significant increase in constitutive DAT endocytosis with a concomitant increase in DAT localization to recycling endosomes. Taken together, these data provide evidences regarding the role of Cdk5/p35 in DAT expression and function, thus ...
Source: Experimental Neurology - Category: Neurology Authors: Source Type: research
Parents of children with ADHD typically report higher levels of parenting stress than parents of typically developing children. Children with ADHD display developmentally inappropriate levels of hyperactivity, impulsivity, and inattention. Some children wi...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news
Translational Psychiatry, Published online: 18 September 2021; doi:10.1038/s41398-021-01604-3Machine-learning-based diagnosis of drug-naive adult patients with attention-deficit hyperactivity disorder using mismatch negativity
Source: Translational Psychiatry - Category: Psychiatry Authors: Source Type: research
Impulsivity is associated with several psychiatric disorders, including substance use disorders (SUD) and attention deficit hyperactivity disorder (ADHD). A widely used questionnaire to assess impulsivity is t...
Source: BMC Psychiatry - Category: Psychiatry Authors: Tags: Research Source Type: research
Condition:   ADHD Intervention:   Behavioral: Attention Deficit Hyperactivity Disorder Treatment Decision Aid Sponsors:   Massachusetts General Hospital;   Center for Survey Research, University of Massachusetts, Boston Completed
Source: - Category: Research Source Type: clinical trials
Epilepsy Behav. 2021 Sep 14;124:108311. doi: 10.1016/j.yebeh.2021.108311. Online ahead of print.ABSTRACTExcessive daytime sleepiness (EDS) and attentional deficits are often observed in people with epilepsy. They may be the consequence of seizures and subclinical discharges as well as of comorbid conditions as obstructive sleep apnea/hypopnea syndrome (OSAS), attention deficit hyperactivity disorder (ADHD), or other less frequent disorders. Excessive daytime sleepiness may also be caused or worsened by antiseizure medications (ASMs). Several meta-analyses suggested that lamotrigine, lacosamide, and perhaps eslicarbazepine ...
Source: Epilepsy and Behaviour - Category: Neurology Authors: Source Type: research
Gambling Disorder (GD) has been recently re-classified in the DSM-5 under the “substance-related and addictive disorders,” in light of its genetic, endophenotypic, and phenotypic resemblances to substance dependence. Diminished control is a core defining concept of psychoactive substance dependence or addiction and has given rise to the concept of “behavioral” addictions, which are syndromes analogous to substance addiction, but with a behavioral focus other than ingestion of a psychoactive substance. The main symptom clusters are represented by loss of control, craving/withdrawal, and neglect of ot...
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
We examined the extent to which attention-deficit/hyperactivity disorder (ADHD), a neurodevelopmental disorder, is linked with Alzheimer’s disease (AD) and any dementia, neurodegenerative diseases, across generations… Results: Among relatives of 2,132,929 index persons, 3042 parents, 171,732 grandparents, and 1369 uncles/aunts had a diagnosis of AD. Parents of individuals with ADHD had an increased risk of AD (hazard ratio 1.55, 95% confidence interval 1.26–1.89). The associations attenuated but remained elevated in grandparents and uncles/aunts. The association for early-onset AD was stronger than late-...
Source: SharpBrains - Category: Neuroscience Authors: Tags: Attention & ADD/ADHD Brain/ Mental Health Alzheimers-disease attention-deficit/hyperactivity disorder cognitive cognitive decline cognitive-abilities dementia neurodegenerative-diseases Neurodevelopmental Source Type: blogs
CONCLUSIONS: Caregivers make decisions on when to visit the hospital based on the child's expression of pain and their behavior. The creation of guidelines to give appropriate guidance to caregivers as to when to visit the hospital is essential.PMID:34526461 | DOI:10.1272/jnms.JNMS.2022_89-214
Source: Journal of Nippon Medical School - Category: Universities & Medical Training Authors: Source Type: research
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