Genetic determinants of the humoral immune response in MS

Conclusion Although some HLA alleles seem to primarily drive the extent of humoral immune responses in the CNS by increasing CSF B cells and plasmablasts, genetic variants at the immunoglobulin heavy chain constant locus might regulate intrathecal immunoglobulins levels via different mechanisms.

http://nn.neurology.org/cgi/content/short/7/5/e827?rss=1

Source: Neurology Neuroimmunology and Neuroinflammation - July 15, 2020 Category: Neurology Authors: Gasperi, C., Andlauer, T. F. M., Keating, A., Knier, B., Klein, A., Pernpeintner, V., Lichtner, P., Gold, R., Zipp, F., Then Bergh, F., Stangel, M., Tumani, H., Wildemann, B., Wiendl, H., Bayas, A., Kümpfel, T., Zettl, U. K., Linker, R. A., Zieman Tags: Autoimmune diseases, Cerebrospinal Fluid, Multiple sclerosis, Association studies in genetics Article Source Type: research