Down regulating PHGDH affects the lactate production of sertoli cells in varicocele.

CONCLUSIONS: Overall, we conformed that varicocele lead to the decreasing of testis lactate production. Down-regulation of PHGDH in sertoli cells may mediate the process of abnormal glucose metabolism. Our study provide new insight into the mechanisms underlying metabolism-associated male infertility and suggests a novel therapeutic target for male infertility.
PMID: 32664979 [PubMed - in process]

Source: Reproductive Biology - July 13, 2020 Category: Reproduction Medicine Authors: Guo WB, Huang ZH, Yang C, Lv XY, Xia H, Tian H, Yang JK, Zhou QZ, Chen MK, Xue KY, Liu CD Tags: Reprod Biol Endocrinol Source Type: research