Trained immunity as a molecular mechanism for BCG immunotherapy in bladder cancer

Nature Reviews Urology, Published online: 16 July 2020; doi:10.1038/s41585-020-0346-4The precise mechanism of action by which BCG acts in bladder cancer therapy is unclear. BCG induces a non-specific enhancement of the biological function of innate immune cells, creating an immunological memory known as trained immunity. In this Perspective, the authors propose that trained immunity could be an important mechanism mediating BCG immunotherapy and could contribute to a personalized approach to BCG therapy in patients with bladder cancer.

Source: Nature Reviews Urology - July 15, 2020 Category: Urology & Nephrology Authors: Jelmer H. van Puffelen Samuel T. Keating Egbert Oosterwijk Antoine G. van der Heijden Mihai G. Netea Leo A. B. Joosten Sita H. Vermeulen Source Type: research