Dimethyl fumarate suppresses metastasis and growth of melanoma cells by inhibiting the nuclear translocation of NF- κB

Melanoma is among the most aggressive forms of human cancer, with an increasing incidence worldwide [1]. Despite recent advancements leading to novel therapies, such as molecular-targeted treatments [2], metastatic melanoma has considerably poor prognoses with low 5-year survival rates 16% [3]. Therefore, novel therapies for metastatic melanoma need to be developed.

Source: Journal of Dermatological Science - July 15, 2020 Category: Dermatology Authors: Tomoya Takeda, Masanobu Tsubaki, Ryota Asano, Tatsuki Itoh, Motohiro Imano, Takao Satou, Shozo Nishida Source Type: research