Nucleolin and nucleophosmin expression patterns in pulmonary adenocarcinoma invading the pleura and in pleural malignant mesothelioma

ConclusionsThe results of our study suggested that lower nucleolin and higher nucleophosmin expression may be related to higher invasiveness of adenocarcinoma of the lung. Differences in nucleolin expression between pulmonary adenocarcinoma and malignant mesothelioma indicate another aspect of biology of these pleura ‐invading cancers that requires further study.Key pointsSignificant findings of the studyDifferences in nucleolin and nucleophosmin expression in pleura invading pulmonary adenocarcinoma indicate the involvement of these proteins in its locoregional spread while differences in nucleolin expression between pulmonary adenocarcinoma and malignant mesothelioma suggest another aspect of biology of these cancers.What this study addsThis is the first study on nucleolin and nucleophosmin expression in pleural malignant mesothelioma and pleura ‐invading pulmonary adenocarcinoma. Our findings may assist in understanding the mechanisms of locoregional spread of adenocarcinoma and differences between these two pleura‐invading cancers.

Source: Thoracic Cancer - July 15, 2020 Category: Cancer & Oncology Authors: Marek Masiuk, Piotr Waloszczyk, Magdalena Lewandowska, Ewa Dobak, Elzbieta Urasinska Tags: ORIGINAL ARTICLE Source Type: research