DNA methylation in children with prenatal methamphetamine exposure and environmental adversity.

CONCLUSIONS: Prenatal MA exposure is related to postnatal childhood adversity and epigenetic alterations in HSD11B2, an important gene along the stress response pathway suggesting prenatal and postnatal programming effects.
IMPACT: Prenatal methamphetamine exposure has been associated with developmental issues in newborns, yet little is known about the stress pathophysiology of methamphetamine on neurobehavior.This is the first evidence that prenatal methamphetamine exposure acts as a stressor, confirming the third pathophysiology of methamphetamine exposure.
PMID: 32663835 [PubMed - as supplied by publisher]

Source: Pediatric Research - July 13, 2020 Category: Pediatrics Authors: Oni-Orisan OO, Dansereau LM, Marsit CJ, Smith LM, Neal CR, Della Grotta SA, Padbury JF, Lester BM Tags: Pediatr Res Source Type: research