GSE152711 Sex-Specific Programming of Cardiac DNA Methylation by Developmental Phthalate Exposure

Contributors : Dana Dolinoy ; Maureen Sartor ; Justin Colacino ; Laurie Svoboda ; Jaclyn Goodrich ; Kai Wang ; Kari Neier ; Christine Rygiel ; Tamara Jones ; Raymond Cavalcante ; Claudia Lalancette ; Siyu LiuSeries Type : Methylation profiling by high throughput sequencingOrganism : Mus musculusPhthalate plasticizers are ubiquitous chemicals linked to several cardiovascular diseases in animal models and in humans. In spite of this, the mechanisms by which phthalate exposures cause adverse cardiac health outcomes are unclear. In particular, whether phthalate exposures during pregnancy interfere with normal developmental programming of the cardiovascular system, and the resulting implications this may have for long-term disease risk, are unknown. Recent studies suggest that the effects of phthalates on metabolic and neurobehavioral outcomes are sex-specific. However, the influence of sex on cardiac susceptibility to phthalate exposures has not been investigated. One mechanism by which developmental exposures may influence long-term health is through altered programming of DNA methylation. In this work, we utilized an established mouse model of human-relevant perinatal exposure and enhanced reduced representation bisulfite sequencing to investigate the long-term effects of diethylhexyl phthalate (DEHP) exposure on DNA methylation in the hearts of adult male and female offspring at 5 months of age (n=5-7 mice per sex and exposure). Perinatal DEHP exposure led to hundr...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Methylation profiling by high throughput sequencing Mus musculus Source Type: research