JNK inhibition alleviates oxidative DNA damage, germ cell apoptosis, and mitochondrial dysfunction in testicular ischemia reperfusion injury.

In conclusion, JNK signaling regulates oxidative DNA damage, GCA, and mitochondrial dysfunction through activation of p53 and suppression of survivin during tIRI.
PMID: 32662511 [PubMed - as supplied by publisher]

Source: Acta Biochimica et Biophysica Sinica - July 13, 2020 Category: Biochemistry Authors: Fadel F, Al-Kandari N, Khashab F, Al-Saleh F, Al-Maghrebi M Tags: Acta Biochim Biophys Sin (Shanghai) Source Type: research