Identification of histone malonylation in the human fetal brain and implications for diabetes ‐induced neural tube defects

ConclusionOur results present a comprehensive map of histone malonylation in the human fetal brain. Furthermore, we provide experimental evidence supporting a relationship between histone malonylation and NTDs caused by high glucose ‐induced diabetes. These findings offer new insights into the pathological role of histone modifications in human NTDs.

Source: Molecular Genetics & Genomic Medicine - July 14, 2020 Category: Genetics & Stem Cells Authors: Qin Zhang, Tanxi Cai, Zonghui Xiao, Dan Li, Chunlei Wan, Xiaodai Cui, Baoling Bai Tags: ORIGINAL ARTICLE Source Type: research