Changes in peripheral mitochondrial DNA copy number in metformin-treated women with polycystic ovary syndrome: a longitudinal study.

CONCLUSIONS: Treatment with metformin is associated with a time-dependent decrease in mtDNA-CN in patients with PCOS who are treated over the course of one year. This may signify a reduction in mitochondria dysfunction. The change in mtDNA-CN corresponds to a similar change in serum total testosterone, and suggests a possible relationship between mtDNA-CN and testosterone.
TRIAL REGISTRATION: ClinicalTrials.gov , NCT00172523 . Registered September 15, 2005.
PMID: 32660613 [PubMed - in process]

Source: Reproductive Biology - July 12, 2020 Category: Reproduction Medicine Authors: Yang PK, Chou CH, Chang CH, Chen SU, Ho HN, Chen MJ Tags: Reprod Biol Endocrinol Source Type: research