Antinociceptive Effects of Shenling Baizhu through PI3K-Akt-mTOR Signaling Pathway in a Mouse Model of Bone Metastasis with Small-Cell Lung Cancer.

Antinociceptive Effects of Shenling Baizhu through PI3K-Akt-mTOR Signaling Pathway in a Mouse Model of Bone Metastasis with Small-Cell Lung Cancer. Evid Based Complement Alternat Med. 2020;2020:4121483 Authors: Feng Z, Feng Z, Han J, Cheng W, Su B, Mo J, Feng X, Feng S, Chen G, Huang P, Huang L, Cui Z Abstract Shenling Baizhu additive powder (SLBZ-AP), a formulation of a variety of natural medicinal plants, has clinical efficacy in treating cancers in previous studies. We explored the effect of SLBZ-AP in bone metastasis of lung cancer (BMLC) mice, and the possible mechanism involved was further investigated in the present study. Mice model of BMLC was made and treated with SLBZ-AP. Pain behavioral tests were performed to explore the effect on BMLC-induced pain in mice. TUNEL staining was used to investigate apoptosis. The mRNA expression of markers in the PI3K/Akt/mTOR pathway was measured by qPCR, and protein expression was detected by western blotting and immunohistochemistry analysis. SLBZ-AP relieved BMLC-induced pain and prolonged animals' survival, promoted cell apoptosis in the marrow from the tibia of BMLC mice, and inhibited mRNA and protein expression of AKT, mTOR, P70S6, and VEGF, as well as protein expression of p-AKT, p-mTOR, p-P70S6, and VEGF upregulation in the marrow of tibia induced by BMLC, an effect which was similar to rapamycin. Our results suggested that SLBZ-AP may have antinociceptive effect and prolong survival of BMLC mice at le...
Source: Evidence-based Complementary and Alternative Medicine - Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

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This study will systematically evaluate the efficacy and safety of cinobufacini combined with vinorelbine and cisplatin in the treatment of stage III/IV non-small cell lung cancer. The results of this systematic review will be published in peer-reviewed scientific journals. Ethics: The ethical approval is not required since systematic review is based on published studies. INPLASY registration number: INPLASY202060091.
Source: Medicine - Category: Internal Medicine Tags: Research Article: Study Protocol Systematic Review Source Type: research
This study investigated the safety and effectiveness of posterior decompression surgery and radiofrequency ablation followed by vertebroplasty in spinal metastasis from lung cancer. MATERIAL AND METHODS From June 2008 to September 2015, a retrospective analysis was conducted in 15 patients with spinal metastasis from lung cancer. All cases suffered MESCC and underwent posterior decompression surgery to relieve the compression of spinal cord, and had radiofrequency ablation followed by vertebroplasty. All patients received postoperative multidisciplinary therapy. The operative time, blood loss, complications, pain, neurolog...
Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research
CONCLUSION: Efforts should be made to ensure that access to Specialist Palliative Care is commensurate with chronic obstructive pulmonary disease's substantial and long-lasting burden. Future research should clarify whether managing burden in chronic obstructive pulmonary disease and lung cancer requires different approaches. PMID: 32720568 [PubMed - as supplied by publisher]
Source: Palliative Medicine - Category: Palliative Care Authors: Tags: Palliat Med Source Type: research
Rationale: A deep neck infection (DNI) with descending necrotizing mediastinitis (DNM) has great clinical importance because of its high morbidity and mortality, particularly when associated with predisposing underlying disease. With the expanding clinical use of 18F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT), it may be necessary to perform FDG PET/CT for immediate diagnosis and treatment of DNM. To the best of our knowledge, this is the first case report of DNI with DNM diagnosed based on FDG PET/CT findings. Patient concerns: A 65-year-old man who underwent chemotherapy for st...
Source: Medicine - Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research
  At one point, Gabe weighed more than 550 pounds. Today, he and Lisa remember and discuss the extreme pain and slow healing process of living with binge-eating disorder. Gabe shares his shame in being so overweight, his intense relationship with food, the story of his gastric bypass and the difficult process of learning new coping mechanisms. How did Gabe’s bipolar and panic attacks tie in with his binge eating? And, importantly, how is he managing the illness today? Join us for an open and honest discussion on living with an eating disorder. (Transcript Available Below) Please Subscribe to Our Show: And We...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Binge Eating Disorders Eating Disorders General Not Crazy Podcast Source Type: blogs
CONCLUSIONS: Our results indicate that a number of physical, social and emotional HRQOL domains are relevant after lobectomy for lung cancer. These domains are currently represented by PROMIS measures and can be readily assessed for clinical or research purposes. PMID: 32707197 [PubMed - as supplied by publisher]
Source: The Annals of Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Authors: Tags: Ann Thorac Surg Source Type: research
Source: Cancer Management and Research - Category: Cancer & Oncology Tags: Cancer Management and Research Source Type: research
THE DEVELOPMENT of enhanced recovery after surgery has encouraged the evolution of opioid-sparing techniques and opioid-free anesthesia (OFA).1,2 In addition, the use of intraoperative opioids can be associated with postoperative hyperalgesia and tolerance, leading to higher pain scores and increased opioid consumption.3,4 Furthermore, the opioid epidemic and chronic long-term opioid usage have been attributed, in part, to the use of opioids in the perioperative period.5,6 The administration of intraoperative opioids in oncologic surgery also has been implicated as a potential causative agent for cancer recurrence.
Source: Journal of Cardiothoracic and Vascular Anesthesia - Category: Anesthesiology Authors: Tags: Original Article Source Type: research
Basel, 13 July 2020 – Roche (SIX: RO, ROG; OTCQX: RHHBY) today announced that the Phase III IMagyn050 study showed that the addition of Tecentriq® (atezolizumab) to Avastin® (bevacizumab), paclitaxel and carboplatin did not meet its primary endpoint of progression-free survival (PFS) for the front-line treatment of women with newly diagnosed advanced stage ovarian cancer. Topline safety data indicate that safety for Tecentriq in combination with Avastin, paclitaxel and carboplatin was consistent with the known safety profile of the combination.“Ovarian cancer remains one of the most aggressive cancers a...
Source: Roche Media News - Category: Pharmaceuticals Source Type: news
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Source: Daily Express - Health - Category: Consumer Health News Source Type: news
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