The E3 ubiquitin ligase MARCH1 regulates antimalaria immunity through interferon signaling and T cell activation [Microbiology]

Malaria infection induces complex and diverse immune responses. To elucidate the mechanisms underlying host–parasite interaction, we performed a genetic screen during early (24 h) Plasmodium yoelii infection in mice and identified a large number of interacting host and parasite genes/loci after transspecies expression quantitative trait locus (Ts-eQTL) analysis. We next...

Source: Proceedings of the National Academy of Sciences - July 13, 2020 Category: Science Authors: Jian Wu, Lu Xia, Xiangyu Yao, Xiao Yu, Keyla C. Tumas, Wenxiang Sun, Yang Cheng, Xiao He, Yu-chih Peng, Brajesh K. Singh, Cui Zhang, Chen-Feng Qi, Silvia Bolland, Sonja M. Best, Channe Gowda, Ruili Huang, Timothy G. Myers, Carole A. Long, Rong-Fu Wang, Xi Tags: Biological Sciences Source Type: research