IL-38 inhibits microglial inflammatory mediators and is decreased in amygdala of children with autism spectrum disorder [Immunology and Inflammation]

Autism spectrum disorder (ASD) is characterized by impaired social interactions and communication. The pathogenesis of ASD is not known, but it involves activation of microglia. We had shown that the peptide neurotensin (NT) is increased in the serum of children with ASD and stimulates cultured adult human microglia to secrete...

Source: Proceedings of the National Academy of Sciences - July 13, 2020 Category: Science Authors: Irene Tsilioni, Harry Pantazopoulos, Pio Conti, Susan E. Leeman, Theoharis C. Theoharides Tags: Biological Sciences Source Type: research