Mechanism of {beta}-arrestin recruitment by the {mu}-opioid G protein-coupled receptor [Biophysics and Computational Biology]

Agonists to the μ-opioid G protein-coupled receptor (μOR) can alleviate pain through activation of G protein signaling, but they can also induce β-arrestin activation, leading to such side effects as respiratory depression. Biased ligands to μOR that induce G protein signaling without inducing β-arrestin signaling can alleviate pain while reducing...

http://www.pnas.org/content/117/28/16346.short?rss=1

Source: Proceedings of the National Academy of Sciences - July 13, 2020 Category: Science Authors: Amirhossein Mafi, Soo-Kyung Kim, William A. Goddard III Tags: Biological Sciences Source Type: research