Structural basis for the broad substrate specificity of two acyl-CoA dehydrogenases FadE5 from mycobacteria [Biochemistry]

FadE, an acyl-CoA dehydrogenase, introduces unsaturation to carbon chains in lipid metabolism pathways. Here, we report that FadE5 from Mycobacterium tuberculosis (MtbFadE5) and Mycobacterium smegmatis (MsFadE5) play roles in drug resistance and exhibit broad specificity for linear acyl-CoA substrates but have a preference for those with long carbon chains. Here,...

Source: Proceedings of the National Academy of Sciences - July 13, 2020 Category: Science Authors: Xiaobo Chen, Jiayue Chen, Bing Yan, Wei Zhang, Luke W. Guddat, Xiang Liu, Zihe Rao Tags: Biological Sciences Source Type: research