Pharmacological disruption of the Notch transcription factor complex [Applied Biological Sciences]
Notch pathway signaling is implicated in several human cancers. Aberrant activation and mutations of Notch signaling components are linked to tumor initiation, maintenance, and resistance to cancer therapy. Several strategies, such as monoclonal antibodies against Notch ligands and receptors, as well as small-molecule γ-secretase inhibitors (GSIs), have been developed to...
Source: Proceedings of the National Academy of Sciences - Category: Science Authors: Raȷwinder Lehal, Jelena Zaric, Michele Vigolo, Charlotte Urech, Viktoras Frismantas, Nadine Zangger, Linlin Cao, Adeline Berger, Irene Chicote, Sylvain Loubery, Sung Hee Choi, Ute Koch, Stephen C. Blacklow, Hector G. Palmer, Beat Bornhauser, Marcos Tags: Biological Sciences Source Type: research