Etiology of candidemia in patients with solid tumors - 7 years of experience of one oncology center.

Etiology of candidemia in patients with solid tumors - 7 years of experience of one oncology center. Neoplasma. 2020 Jul 14;: Authors: Szymankiewicz M, Nowikiewicz T Abstract Although the candidemia still remains a serious health problem, the study of candidemia in cancer patients is limited. We conducted a retrospective analysis of candidemia among 31 adult patients hospitalized in one oncological center. The mean annual incidence of candidemia was 0.14 ± 0.05 / 1000 patient-days (range 0.04-0.91). In 10 patients (32.3%), the catheter-related infection was diagnosed; in the remaining 21 patients (67.7%), it was a secondary infection. From 31 patients of candidemia, 15 died (48.4% 30-day mortality), but an overall mortality rate during hospital stay was 61.3% (19 cases). Patients with secondary candidemia, ASA = IV and complicated postoperative course, had poorer 1-year survival probability compared with patients with catheter-related infection (p = 0.004), ASA < IV (p = 0.0393) and uncomplicated postoperative course (p = 0.0009). C. glabrata (n = 13, 41.9%) was the most frequently isolated species, followed by C. albicans (n = 12, 38.7%) and C. parapsilosis (n= 3, 9.7%). C. lusitaniae (n = 2, 6.5%), and C. tropicalis (n = 1, 3.2%) were sporadically isolated. Within C. glabrata, there was no resistance to anidulafungin, two strains (15.4%) were resistant to fluconazole, while the others showed intermediate susceptibilities to thi...
Source: Neoplasma - Category: Cancer & Oncology Authors: Tags: Neoplasma Source Type: research