Inhibiting protein kinase activity of pyruvate kinase M2 by sirtuin 2 deacetylase attenuates psoriasis

In this study, we investigated whether and how sirtuin 2 (Sirt2) deacetylase regulated the protein kinase function of PKM2 in Th17 cell-mediated inflammatory responses in psoriasis. Sirt2 KO mice and WT littermates had psoriatic dermatitis induced by topical treatment of imiquimod or intradermal injection of recombinant IL-23.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Original Article Source Type: research