Dorsal Root Ganglion Stimulation Alleviates Pain-related Behaviors in Rats with Nerve Injury and Osteoarthritis

Conclusions Dorsal root ganglion stimulation is effective in neuropathic and osteoarthritic preclinical rat pain models with peripheral pathologic origins, demonstrating effectiveness of ganglion stimulation in a placebo-free setting and justifying this model as a suitable platform for mechanistic studies.Editor ’s PerspectiveWhat We Already Know about This TopicDorsal root ganglion stimulation is a new approach to neuromodulation for the purpose of achieving pain reliefNeuromodulation research has been slowed by the lack of well characterized animal modelsWhat This Article Tells Us That Is NewUsing a rat model of osteoarthritis, stimulation of both the L3 and L4 dorsal root ganglia reduced nonreflexive knee motion scores and provided conditioned place preference more than sham stimulationSensitization from peripheral nerve injury responded to stimulation maximally when provided at two ganglia (L4 and L5)versus just one
Source: Anesthesiology - Category: Anesthesiology Source Type: research