Dexmedetomidine Exerts an Anti-inflammatory Effect via α 2 Adrenoceptors to Prevent Lipopolysaccharide-induced Cognitive Decline in Mice

Conclusions Preclinical studies suggest that the cognitive benefit provided by dexmedetomidine in mice administered lipopolysaccharide is mediated through α2 adrenoceptor –mediated anti-inflammatory pathways.Editor ’s PerspectiveWhat We Already Know about This TopicAdministration of lipopolysaccharide to young and middle-aged mice is associated with neuroinflammation and cognitive impairmentDexmedetomidine has been shown to decrease neuroinflammation in miceWhat This Article Tells Us That Is NewAdministration of dexmedetomidine to mice treated with lipopolysaccharide decreased neuroinflammation and cognitive impairment in both young and aged miceThe effects of dexmedetomidine on neuroinflammation and cognitive impairment in mice treated with lipopolysaccharide are likely mediated by α2 adrenoceptor –mediated anti-inflammatory pathways

Source: Anesthesiology - July 14, 2020 Category: Anesthesiology Source Type: research