Cellular kinetics of hematopoietic cells with Sfpi1 deletion are present at different frequencies in bone-marrow and spleen in X-irradiated mice.

CONCLUSIONS: The frequency of HRCs with HDSG in both bone marrow and spleen was increased 1 week after X-irradiation. Then, the frequency of HRCs with HDSG in bone marrow showed a gradual decrease from 4 to 26 weeks, whereas HRCs with HDSG in spleen remained high, even at 26 weeks after X-irradiation. The different responses may reflect differences in hematopoietic cell dynamics in bone marrow and spleen. HDSG is less likely to be eliminated, particularly in the spleen, after X-irradiation. The spleen as well as bone marrow of the femur may be major sites of rAML development. PMID: 32658559 [PubMed - as supplied by publisher]
Source: International Journal of Radiation Biology - Category: Radiology Tags: Int J Radiat Biol Source Type: research