From Embryo to Adult: One Carbon Metabolism in Stem Cells.

From Embryo to Adult: One Carbon Metabolism in Stem Cells. Curr Stem Cell Res Ther. 2020 Jul 12;: Authors: Altundag Ö, Çelebi-Saltik B Abstract Stem cells are undifferentiated cells with self-renewal property with varying differentiation potential that allow the regeneration of tissue cells of an organism throughout adult life beginning with embryonic development. Through the asymmetric cell divisions, each stem cell replicates itself and produces an offspring identical with the mother cell, and a daughter cell that posses the characteristics of a progenitor cell and commits to a specific lineage to differentiate into tissue cells to maintain homeostasis. To maintain a pool of stem cells to ensure tissue regeneration and homeostasis, it is important to regulate the metabolic functioning of stem cells, progenitor cells and adult tissue stem cells that will meet their internal and external needs. Upon fertilization, the zygote transforms metabolic reprogramming while implantation, embryonic development, organogenesis processes and after birth through adult life. Metabolism in stem cells is a concept that is relatively new to be enlightened. There are no adequate and comprehensives in vitro studies on the comparative analysis of the effects of one-carbon (1-C) metabolism on fetal and adult stem cells compared to embryonic and cancer stem cells' studies that have been reported recently Since 1-C metabolism is linking parental environme...
Source: Current Stem Cell Research and Therapy - Category: Stem Cells Authors: Tags: Curr Stem Cell Res Ther Source Type: research