Antibacterial flavonoids and other compounds from the aerial parts of Vernonia guineensis Benth. (Asteraceae) †.
Antibacterial flavonoids and other compounds from the aerial parts of Vernonia guineensis Benth. (Asteraceae)†.
Chem Biodivers. 2020 Jul 13;:
Authors: Kouam SF, Wouamba SCN, Happi GM, Pouofo MN, Tchamgoue J, Longo F, Jouda JB, Lenta BN, Sewald N
Abstract
An extensive phytochemical study of the aerial parts of Vernonia guineensis Benth. (Asteraceae) led to the isolation of a new flavone, vernoguinoflavone (1) and a naturally isolated glycerol ester, bisarachidicester (2), together with eighteen known secondary metabolites including quercetin (3), luteolin (4), vernopicrin (5), vernomelitensin (6), β-amyrin (7), oleanolic acid (8), ursolic acid (9), lupeol (10), betulinic acid (11), β-carotene (12), a mixture of stigmasterol (13) and β-sitosterol (14), β-sitosterol-3-O-β-D-glucoside (15), 2,3-dihydroxypropyl heptacosanoate (16), pentacosanoic acid (17), docosan-1-ol (18), tritriacontan-1-ol (19), and heptatriacontan-1-ol (20). Compounds 3, 4, 7-9, 12 and 16-20 are reported herein for the first time from this species. The structures of these compounds were elucidated based on extensive spectroscopic analyses, particularly 1D and 2D NMR, and HR-ESI-MS and by comparison of their data with those reported in the literature. The crude extract, fractions and some isolated compounds were evaluated for their antibacterial activity against Gram-negative bacteria: Escherichia coli (ATCC 25922), Shigella flexineri (NR 518), Salmonella Muenc...
Source: Chemistry and Biodiversity - Category: Biochemistry Authors: Kouam SF, Wouamba SCN, Happi GM, Pouofo MN, Tchamgoue J, Longo F, Jouda JB, Lenta BN, Sewald N Tags: Chem Biodivers Source Type: research