A 16-year retrospective study on fungal prevalence and diversity in patients with cystic fibrosis: Candida dubliniensis was associated with a decline in lung function

Progressive lung disease is still the main cause of death in cystic fibrosis (CF) patients (O ’Sullivan and Freedman, 2009). In the CF lung, viscous secretions, impaired mucociliary clearance and insufficient local immune responses result in bacterial and fungal colonization, and subsequent chronic inflammation (Cohen and Prince, 2012) Over the last decade, fungi have been increasingly det ected from the respiratory tract in CF patients (Chotirmall et al., 2010a; Chotirmall and McElvaney, 2014). Advanced microbiological detection methods, extensive and liberal use of antibiotics and an aging CF population have been suggested to lie behind this increasing detection rate (Galant et al., 1976; Burns et al., 1996).
Source: International Journal of Infectious Diseases - Category: Infectious Diseases Authors: Source Type: research