Molecules, Vol. 25, Pages 3182: Versatile Polypeptide-Functionalized Plasmonic Paper as Synergistic Biocompatible and Antimicrobial Nanoplatform
Molecules, Vol. 25, Pages 3182: Versatile Polypeptide-Functionalized Plasmonic Paper as Synergistic Biocompatible and Antimicrobial Nanoplatform
Molecules doi: 10.3390/molecules25143182
Authors:
Leopold Tie
Mina Răileanu
Mihaela Bacalum
Irina Codita
Ștefania Mădălina Negrea
Costin Ștefan Caracoti
Elena-Carmina Drăgulescu
Andreea Campu
Simion Astilean
Monica Focsan
Nowadays, thanks to nanotechnological progress, which itself guides us more and more closely toward not only the efficient design of innovative nanomaterials or nanostructures, but to the improvement of their functionality, we benefit from an important asset in the battle against pathogenic illnesses. Herein, we report a versatile biocompatible plasmonic nanoplatform based on a Whatman paper incorporating positively-charged gold nanospherical particles via the immersion approach. The morphological characterization of the as-engineered-plasmonic paper was examined by SEM (scanning electron microscopy) and HRTEM (high-resolution transmission electron microscopy) investigations, while its surface chemical modification with a synthetic polypeptide, specifically RRWHRWWRR-NH2 (P2), was proved by monitoring the plasmonic response of loaded gold nanospheres and the emission signal of P2 via fluorescence spectroscopy. The as-functionalized plasmonic paper is non-cytotoxic towards BJ fibroblast human cells at bactericidal concentrations. Finally, the antimicrobial activity of the P2-functional...
Source: Molecules - Category: Chemistry Authors: Leopold Tie Mina R ăileanu Mihaela Bacalum Irina Codita Ștefania Mădălina Negrea Costin Ștefan Caracoti Elena-Carmina Dr ăgulescu Andreea Campu Simion Astilean Monica Focsan Tags: Article Source Type: research