coagulation profile in severe COVID-19 patients: what do we know so far?

Conclusion: So far no pharmacological intervention was proven effective and safe to warrant its use in the routine treatment of COVID-19 patients; therefore such patients should ideally be treated in the context of clinical trials. The recommendations herein provided will be revised continuously aiming to capture newly generated evidence.
Source: Revista Brasileira de Terapia Intensiva - Category: Intensive Care Source Type: research

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The last time the U.S. experienced a pandemic, advice to working Americans was similar to the message officials are sharing today—stay home. Similar to today’s COVID-19 outbreak, the 2009 H1N1 pandemic laid bare issues of inequality in the U.S., including disparities in paid sick leave. In 2009, the federal government did not have a federal paid sick leave policy, and it still doesn’t today, forcing U.S. workers to make the impossible choice between financial and personal health. But there are important lessons we can learn from the past, says Keshia Pollack Porter, director of the Johns Hopkins Bloomberg...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized Brief COVID-19 News Desk Source Type: news
Countries around the world have introduced stringent control measures to stop COVID-19 outbreaks growing, but now many find themselves facing the same situation again. From Melbourne to Miami, the relaxation of measures had led to increasing flare-ups, which in some places has already meant reclosing schools, businesses or travel routes. Within the U.S. and among different countries, places with wildly varying public-health policies have experienced wildly diverse outcomes. Most ominously, infections are rising rapidly in many places where they once were falling. So how do countries avoid an indefinite, unsustainable, cycl...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized COVID-19 Source Type: news
Source: BMJ Comments - Category: General Medicine Source Type: forums
My boys do not want to wear pants.A small factor, but part of the reason they campaigned for remote learning. My daughter, who generally prefers clothing, remained on the fence.The remote vs. in-person learning decision has so many different factors it is very difficult as a pediatrician to give families a single clear answer.As new data emerges, it further confounds a family ’s decision that seemed crystal clear just 2 internet articles ago.Several people have asked point blank, “What are you doing for your own kids?”If I have left your text unanswered or have not replied to your email or Facebook commen...
Source: A Pediatrician's Blog - Category: Pediatrics Source Type: blogs
Abstract The study aims to describe patients hospitalized for severe acute respiratory illness (SARI) due to COVID-19 (SARI-COVID) in Brazil according to demographic characteristics and comorbidities up to the 21st Epidemiological Week of 2020. The study aimed to compare these characteristics with those of patients hospitalized for SARI due to influenza in 2019/2020 (SARI-FLU) and with the Brazilian general population. The proportions of demographic characteristics, comorbidities, and pregnant and postpartum women among patients hospitalized for SARI-COVID and SARI-FLU were obtained from the SIVEP-Gripe database, ...
Source: Cadernos de Saude Publica - Category: International Medicine & Public Health Authors: Tags: Cad Saude Publica Source Type: research
The new coronavirus SARS-CoV-2, the cause of COVID-19, has become a public health emergency of global concern. Like the SARS and influenza pandemics, there have been a large number of cases coinfected with other viruses, fungi, and bacteria, some of which originate from the oral cavity. Capnocytophaga, Veillonella, and other oral opportunistic pathogens were found in the BALF of the COVID-19 patients by mNGS. Risk factors such as poor oral hygiene, cough, increased inhalation under normal or abnormal conditions, and mechanical ventilation provide a pathway for oral microorganisms to enter the lower respiratory tract and th...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
Abstract We compared indicators of influenza activity in 2020 before and after public health measures were taken to reduce coronavirus disease (COVID-19) with the corresponding indicators from 3 preceding years. Influenza activity declined substantially, suggesting that the measures taken for COVID-19 were effective in reducing spread of other viral respiratory diseases. PMID: 32339092 [PubMed - indexed for MEDLINE]
Source: Emerging Infectious Diseases - Category: Infectious Diseases Authors: Tags: Emerg Infect Dis Source Type: research
We report a fatal case of this superinfection in a young adult who had coronavirus disease. PMID: 32298228 [PubMed - indexed for MEDLINE]
Source: Emerging Infectious Diseases - Category: Infectious Diseases Authors: Tags: Emerg Infect Dis Source Type: research
By MICHEL ACCAD, MD With cases of COVID-19 either disappeared or rapidly diminishing from places like Wuhan, Italy, New York, and Sweden, many voices are speculating that herd immunity may have been reached in those areas and that it may be at hand in the remaining parts of the world that are still struggling with the pandemic.  Lockdowns should end—or may not have been needed to begin with, they conclude. Adding plausibility to their speculation is the discovery of biological evidence suggesting that prior exposure to other coronaviruses may confer some degree of immunity against SARS-CoV...
Source: The Health Care Blog - Category: Consumer Health News Authors: Tags: COVID-19 Health Policy immunity MICHEL ACCAD Pandemic Source Type: blogs
Purpose of review Although clinical outcomes in the treatment of aspergillosis have markedly improved with the availability of newer triazoles, the development of resistance to these antifungals, especially in Aspergillus fumigatus, is a growing concern. The purpose of this review is to provide an update on azole resistance mechanisms and their epidemiology in A. fumigatus, the clinical implications of azole resistance, and to discuss future treatment options against azole-resistant aspergillosis. Recent findings Resistance may develop through either patient or environmental azole exposure. Environmental exposure is t...
Source: Current Opinion in Infectious Diseases - Category: Infectious Diseases Tags: INFECTIONS OF THE IMMUNOCOMPROMISED HOST: Edited by Barbara D. Alexander and Rachel A. Miller Source Type: research
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