Choice Architecture Based TB Preventive Therapy Prescribing

Conditions:   HIV/AIDS;   Tuberculosis Intervention:   Behavioral: Choice Architecture Sponsors:   Johns Hopkins University;   KNCV Tuberculosis Foundation;   Clinton Health Access Initiative, Zimbabwe;   Aurum Institute Not yet recruiting
Source: - Category: Research Source Type: clinical trials

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AbstractUltraviolet blood irradiation (UBI) was used with success in the 1930s and 1940s for a variety of diseases. Despite the success, the lack of understanding of the detailed mechanisms of actions, and the achievements of antibiotics, phased off the use of UBI from the 1950s. The emergence of novel viral infections, from HIV/AIDS to Ebola, from SARS and MERS, and SARS-CoV-2, bring back the attention to this therapeutical opportunity. UBI has a complex virucidal activity, mostly acting on the immune system response. It has effects on lymphocytes (T-cells and B-cells), macrophages, monocytes, dendritic cells, low-density...
Source: Clinical Reviews in Allergy and Immunology - Category: Allergy & Immunology Source Type: research
This study assessed comorbidities and laboratory parameters in HIV/AIDS inpatients with RF (N = 58) in relation to those without RF (N = 36). Tuberculosis showed a huge relative risk and platelet counts were slightly higher in HIV/AIDS inpatients with RF. A flow cytometry assay for reactive oxygen species (ROS) showed lower levels in platelets of these patients in relation to the healthy subjects. However, when stimulated with adrenaline, ROS levels increased in platelets and platelet-derived microparticles of HIV/AIDS inpatients, which may increase the risk of RF during HIV and tuberculosis (HIV-TB) coinfection. PMID...
Source: Memorias do Instituto Oswaldo Cruz - Category: Infectious Diseases Authors: Tags: Mem Inst Oswaldo Cruz Source Type: research
AbstractPurpose of ReviewDespite broad uptake of antiretroviral therapy (ART), tuberculosis (TB) incidence and mortality among people with HIV remain unacceptably high. Short-course regimens for TB, incorporating both novel and established drugs, offer the potential to enhance adherence and completion rates, thereby reducing the global TB burden. This review will outline short-course regimens for TB among patients with HIV.Recent FindingsAfter many years without new agents, there is now active testing of many novel drugs to treat TB, both for latent infection and active disease. Though not all studies have included patient...
Source: Current HIV/AIDS Reports - Category: Infectious Diseases Source Type: research
Conclusion: Morocco was the first country in the Global Fund's Middle/East North Africa region to invest its entire Global Fund allocation in strengthening the health system. Many important lessons have been learned from this novel experience and these are presented for shared learning. This opportunity for learning is timely as countries begin preparations for the upcoming funding cycle. PMID: 32896891 [PubMed - in process]
Source: Eastern Mediterranean Health Journal - Category: Middle East Health Tags: East Mediterr Health J Source Type: research
In Togo, the National Malaria Control Programme, in collaboration with the Global Fund to Fight AIDS, Tuberculosis and Malaria, has implemented a pilot study for malaria sentinel surveillance since 2017, which...
Source: Malaria Journal - Category: Infectious Diseases Authors: Tags: Research Source Type: research
Conclusion: Despite the known protective effect of cART against tuberculosis, a continuing disproportionately high incidence is seen among Black African people. Results support further interventions to prevent tuberculosis in this group.
Source: AIDS - Category: Infectious Diseases Tags: Epidemiology and Social Source Type: research
[The Herald] PEOPLE living with HIV and those with tuberculosis can now collect their medication from mobile refill centres in Harare.
Source: AllAfrica News: HIV-Aids and STDs - Category: Infectious Diseases Source Type: news
In conclusion, I hope that you will buy this book and share it with your family and friends. It is meant to be a conversation piece. Instead of gathering dust on a bookshelf, it is designed to lie on a living room table (like so many architecture and interior design books), for visitors to see and discuss over a martini or glass of wine. I hope that it will alleviate some depression and anxiety, spark a fact ‐​filled discussion around the dining room table, and maybe even change some minds. Strangers things have happened. Cheers!
Source: Cato-at-liberty - Category: American Health Authors: Source Type: blogs
Natural Polymorphisms in Mycobacterium tuberculosis Conferring Resistance to Delamanid in Drug-naïve Patients. Antimicrob Agents Chemother. 2020 Aug 31;: Authors: Reichmuth ML, Hömke R, Zürcher K, Sander P, Avihingsanon A, Collantes J, Loiseau C, Borrell S, Reinhard M, Wilkinson RJ, Yotebieng M, Fenner L, Böttger EC, Gagneux S, Egger M, Keller PM, International epidemiology Databases to Evaluate AIDS (IeDEA) Abstract Mutations in the genes of the F420 signaling pathway, including dnn, fgd1, fbiA, fbiB, fbiC, and fbiD, of Mycobacterium tuberculosis (Mtb) complex can lead to delamani...
Source: Antimicrobial Agents and Chemotherapy - Category: Microbiology Authors: Tags: Antimicrob Agents Chemother Source Type: research
This article delves into notable success stories of gene therapy which has been regarded as the beacon of medical novelty expected to blossom in the near future to provide a holistic, targeted, precise, and individualistic personalised-medicine as well as laying out the future hopes of gene therapy in the treatment of debilitating diseases such as solid tumours, AIDS, Tuberculosis, Diabetes Mellitus, psychiatric illnesses, which are still at a standstill, from a gene therapy point of view. PMID: 32860369 [PubMed - as supplied by publisher]
Source: Malaysian Journal of Pathology - Category: Pathology Tags: Malays J Pathol Source Type: research
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