Roche provides update on Phase III study of Tecentriq in women with advanced stage ovarian cancer
Basel, 13 July 2020 – Roche (SIX: RO, ROG; OTCQX: RHHBY) today announced that the Phase III IMagyn050 study showed that the addition of Tecentriq® (atezolizumab) to Avastin® (bevacizumab), paclitaxel and carboplatin did not meet its primary endpoint of progression-free survival (PFS) for the front-line treatment of women with newly diagnosed advanced stage ovarian cancer. Topline safety data indicate that safety for Tecentriq in combination with Avastin, paclitaxel and carboplatin was consistent with the known safety profile of the combination.“Ovarian cancer remains one of the most aggressive cancers and is difficult to treat in its advanced stages,” said Levi Garraway, M.D., Ph.D., Roche’s Chief Medical Officer and Head of Global Product Development. “While we are disappointed by these results, we remain committed to improving o utcomes for women living with this disease and are pleased that Avastin remains a key component in the treatment of front-line ovarian cancer.” Data for the overall survival (OS) co-primary endpoint are currently immature and follow-up will continue until the next planned analysis. Results from IMagyn050 will be further evaluated in order to inform the Tecentriq gynaecologic development programme. The Tecentriq programme in ovarian cancer and cervical cancers builds on the combination with Avastin, which has helped women with newly diagnosed, advanced or relapsed ovarian and cervical cancers live without t...
AbstractHuman trafficking is an egregious violation of basic human rights that has reached global proportions. Despite the gradual proliferation of social science research and policy endeavors, a contemporary understanding of state human trafficking statutes has received limited discussion. Existing commentary tends to underserve survivor experiences in the law. Using a database of 982 human trafficking state statutes, this study seeks to describe the landscape of how the law acknowledges survivors. In doing so, we found that states acknowledge survivors through 1. formal agency guidelines, 2. survivor rights and services,...
Contributors : King L Hung ; Kathryn E Yost ; Liangqi Xie ; Quanming Shi ; Konstantin Helmsauer ; Jens Luebeck ; Robert Sch öpflin ; Joshua T Lange ; Rocio Chamorro ; Natasha E Weiser ; Celine Chen ; Maria E Valieva ; Ivy Tsz-Lo Wong ; Sihan Wu ; Siavash R Dehkordi ; Connor V Duffy ; Katerina Kraft ; Jun Tang ; Julia A Belk ; John C Rose ; M R Corces ; Jeffrey M Granja ; Utkrisht Rajkumar ; Jordan Friedlein ; An indya Bagchi ; Ansuman T Satpathy ; Robert Tijan ; Stefan Mundlos ; Vineet Bafna ; Anton G Henssen ; Paul S Mischel ; Zhe Liu ; Howard Y ChangSeries Type : Expression profiling by high throughput sequencingOrg...
New J. Chem., 2021, Advance Article DOI: 10.1039/D1NJ03038H, PaperMehmet Oguz, Berna Dogan, Serdar Durdagi, Asif Ali Bhatti, Serdar Karakurt, Mustafa Yilmaz Although quercetin is an effective bioactive compound preventing the progress of several human cancers, its impact is reduced due to low bioavailability. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
Environ. Sci.: Processes Impacts, 2021, Accepted Manuscript DOI: 10.1039/D1EM00202C, CommunicationMayomi Omebeyinje, Adewale Adeluyi, Chandrani Mitra, Paramita Chakraborty, Gregory Gandee, Nalit Patel, Bindhu Verghese, Christine Farrance, Matthew Hull, Paramita Basu, Kwonmoo Lee, Atin Adhikari, Burcu Adivar, Jennifer Horney, Anindya Chanda Indoor flooding is a leading contributor to indoor dampness and the associated mold infestations in the coastal United States. Whether the prevalent mold genera that infest the coastal flood-prone buildings... The content of this RSS Feed (c) The Royal Society of Chemistry
History of TBI tied to 52 percent increased odds of prescription opioid use, 65 percent increased odds of prescription opioid misuse
October visits help celebrate Breast Cancer Awareness Month.
Conclusion Results may assist clinicians in aiming exercise programs toward increasing hip and potentially core strength, thus improving balance to promote better mobility for individuals with a lower-limb amputation.
Conclusion The results show varying benefits of the microprocessor- and hydraulic-controlled prosthetic components over fixed-ankle ESAR and FK feet, based on both performance-based and patient-reported outcome measures. Further studies are needed to fully evaluate these benefits in larger sample sizes.
Ongoing complications following SARS-CoV-2 infection are associated with increased risk for mortality and treatment cessation.Medscape Medical News
Jichang Han, BS, is the first at Dartmouth to receive a Predoctoral to Postdoctoral Fellow Transition Award (F99/K00) from the National Cancer Institute (NCI) of the National Institutes of Health (NIH).
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