Progressive tau aggregation does not alter functional brain network connectivity in seeded hTau.P301L mice.

Progressive tau aggregation does not alter functional brain network connectivity in seeded hTau.P301L mice. Neurobiol Dis. 2020 Jul 09;:105011 Authors: Detrez JR, Ben-Nejma IRH, Van Kolen K, Van Dam D, De Deyn PP, Fransen E, Verhoye M, Timmermans JP, Nuydens R, Van der Linden A, Keliris GA, De Vos WH Abstract Progressive accumulation of hyperphosphorylated tau is a hallmark of various neurodegenerative disorders including Alzheimer's disease. However, to date, the functional effects of tau pathology on brain network connectivity have been investigated to a limited extent. To directly interrogate the impact of tau pathology on functional brain connectivity, we conducted a longitudinal experiment in which we monitored a seeded hTau.P301L mouse model using correlative whole-brain microscopy and resting-state functional MRI. Despite a progressive aggravation of tau pathology across the brain, the major resting-state networks appeared unaffected up to 15 weeks after seeding. Targeted analyses also showed that the connectivity of regions with high levels of hyperphosphorylated tau was comparable to that observed in controls. In line with the ostensible retention of connectivity, no behavioural changes were detected between seeded and control mice as determined by three different paradigms. Our data indicate that seeded tau pathology, with accumulation of tau aggregates throughout different regions of the brain, does not alter functional ...
Source: Neurobiology of Disease - Category: Neurology Authors: Tags: Neurobiol Dis Source Type: research