How Koalas With an S.T.D. Could Help Humanity

When it comes to finding a vaccine for chlamydia, the world ’s most common sexually transmitted infection, koalas may prove a key ally.
Source: NYT Health - Category: Consumer Health News Authors: Tags: Chlamydia Koalas Animals Sexually Transmitted Diseases Endangered and Extinct Species Antibiotics Vaccination and Immunization Bacteria Veterinary Medicine Queensland (Australia) your-feed-science Source Type: news

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Vaccine. 2021 Mar 24:S0264-410X(21)00326-1. doi: 10.1016/j.vaccine.2021.03.043. Online ahead of print.ABSTRACTChlamydia trachomatis is the causative agent of a highly prevalent sexually transmitted bacterial disease and is associated with a number of severe disease complications. Current therapy options are successful at treating disease, but patients are left without protective immunity and do not benefit the majority asymptomatic patients who do not seek treatment. As such, there is a clear need for a broad acting, protective vaccine that can prevent transmission and protect against symptomatic disease presentation. Ther...
Source: Vaccine - Category: Allergy & Immunology Authors: Source Type: research
Chlamydia trachomatis is an obligate intracellular pathogen that causes sexually transmitted disease. In women, chlamydial infections may cause pelvic inflammatory disease (PID), ectopic pregnancy, and infertility. The role of antibodies in protection against a primary Chlamydia infection is unclear and was a focus of this work. Using the C. muridarum mouse infection model, we show that intestinal mucosa is infected via intranasal (i.n.) or per-oral (p.o.) Chlamydia inoculation and that unlike the female reproductive tract (FRT) mucosa, it halts systemic Chlamydia dissemination. Moreover, p.o. immunization or infection wit...
Source: Infection and Immunity - Category: Infectious Diseases Authors: Tags: Microbial Immunity and Vaccines Source Type: research
In this study it was assumed that there was no immunity following resolution of natural infection. The modeling demonstrated that a vaccine of moderate efficacy could have a significant impact on the prevalence of gonorrhea if strategically implemented (23). While encouraging it does, of course, depend on the availability of a vaccine. From Ecological Data to Evidence The epidemiological evidence from Cuba, Brazil, and New Zealand demonstrates that N. meningitidis OMV vaccines are possibly able to provide some broader protection against meningococcal disease (17, 24), particularly in older children and adults (25). These...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
This study aimed to use 16S rRNA gene sequences derived from koala feces to characterize the intestinal microbiome of koalas throughout antibiotic treatment and identify specific taxa associated with koala health after treatment. Although differences in the alpha diversity were observed in the intestinal flora between treated and untreated koalas and between koalas treated with different antibiotics, these differences were not statistically significant. The alpha diversity of microbial communities from koalas that lived through antibiotic treatment versus those who did not was significantly greater, however. Beta diversity...
Source: The Tree of Life - Category: Microbiology Authors: Source Type: blogs
National institute of allergy and infectious diseases workshop report: "Chlamydia vaccines: the way forward". Vaccine. 2017 Oct 30;: Authors: Zhong G, Brunham RC, de la Maza LM, Darville T, Deal C Abstract Chlamydia trachomatis (Ct), an intracellular pathogen, is the most common bacterial sexually transmitted infection. In addition to acute cervicitis and urethritis, Ct can lead to serious sequelae of significant public health burden including pelvic inflammatory disease (PID) and infertility. Ct control efforts have not resulted in desired outcomes such as reduced incidence and reinfection,...
Source: Vaccine - Category: Allergy & Immunology Authors: Tags: Vaccine Source Type: research
Publication date: 15 July 2017 Source:International Journal of Pharmaceutics, Volume 527, Issues 1–2 Author(s): Ingrid S. Ganda, Qian Zhong, Mirabela Hali, Ricardo L.C. Albuquerque, Francine F. Padilha, Sandro R.P. da Rocha, Judith A. Whittum-Hudson Peptide-based vaccines have emerged in recent years as promising candidates in the prevention of infectious diseases. However, there are many challenges to maintaining in vivo peptide stability and enhancement of peptide immunogenicity to generate protective immunity which enhances clearance of infections. Here, a dendrimer-based carrier system is proposed for peptide-ba...
Source: International Journal of Pharmaceutics - Category: Drugs & Pharmacology Source Type: research
We describe the clinical and public health need for a C. trachomatis vaccine, provide an overview of Chlamydia vaccine development efforts, and summarize current vaccine candidates in the development pipeline. PMID: 28111145 [PubMed - as supplied by publisher]
Source: Vaccine - Category: Allergy & Immunology Authors: Tags: Vaccine Source Type: research
s F Abstract Chlamydia trachomatis infections are the most prominent bacterial sexually-transmitted disease world-wide and a lot of effort is put into the development of an effective vaccine. Pigs have been shown to be a valuable animal model for C. trachomatis vaccine development. The aim of this study was to decipher the T-cell-mediated immune response to chlamydial infections including C. trachomatis and C. suis, the chlamydia species naturally infecting pigs with a demonstrated zoonotic potential. Vaginal infection of pigs with C. suis and C. trachomatis lasted from 3 to 21days and intra-uterine infection was ...
Source: Vaccine - Category: Allergy & Immunology Authors: Tags: Vaccine Source Type: research
Conclusion It's easy to get carried away by headlines about vaccines for common and damaging diseases, but early-stage studies in mice don't always translate into usable vaccines for humans. People have been trying to find an effective vaccine against chlamydia since the bacteria was discovered in 1957, and research is still being carried out into several different vaccine candidates. This vaccine may turn out to be effective, but it could become one of the many failed vaccine candidates seen over the years. This is a small study in just 20 specially bred laboratory mice, and involved a type of chlamydia (Chlamydia muri...
Source: NHS News Feed - Category: Consumer Health News Tags: Lifestyle/exercise Medication Medical practice Source Type: news
Authors: Poston TB, Darville T Abstract Chlamydia trachomatis is the most common cause of sexually transmitted bacterial infection globally. These infections translate to a significant public health burden, particularly women's healthcare costs due to serious disease sequelae such as pelvic inflammatory disease (PID), tubal factor infertility, chronic pelvic pain, and ectopic pregnancy. There is no evidence that natural immunity can provide complete, long-term protection necessary to prevent chronic pathology, making human vaccine development critical. Vaccine design will require careful consideration of protective...
Source: Current Topics in Microbiology and Immunology - Category: Microbiology Tags: Curr Top Microbiol Immunol Source Type: research
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