HSP90 Inhibitor Improves Lung Protection in Porcine Model of Donation after Circulatory Arrest.

CONCLUSIONS: The use of HSP90i with EVLP improves the lung reconditioning process. Further research is required to confirm if these findings translate to benefit once transplanted and observed in-vivo. Successful pharmacological inhibitors may expand the donor pool in the context of DCD donors.
PMID: 32652069 [PubMed - as supplied by publisher]

Source: The Annals of Thoracic Surgery - July 7, 2020 Category: Cardiovascular & Thoracic Surgery Authors: Nasir BS, Landry C, Menaouar A, Germain JF, Sarkissian S, Stevens LM, Aceros H, Cailhier JF, Leduc C, Liberman M, Noiseux N, Ferraro P Tags: Ann Thorac Surg Source Type: research