Multifunctional glutathione-dependent hydrogel eye drops with enhanced drug bioavailability for glaucoma therapy

Publication date: 15 December 2020Source: Chemical Engineering Journal, Volume 402Author(s): Jui-Yang Lai, Li-Jyuan Luo, Duc Dung Nguyen
Source: Chemical Engineering Journal - Category: Chemistry Source Type: research

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Conclusion: Intraoperative imaging of the gonio structures including the trabeculotomy cleft was feasible using the ARTEVO 800 with iOCT in combination with a gonioprism. PMID: 32724670 [PubMed]
Source: Journal of Ophthalmology - Category: Opthalmology Tags: J Ophthalmol Source Type: research
Conclusion: Introduction of this support system with SoC is cost-effective and will lead to blindness reduction in Japanese patients with glaucoma. Over a 20 year period, it will lead to an overall cost savings of 1,132 billion yen (10 billion US dollars) for the Japanese healthcare system. PMID: 32729756 [PubMed - as supplied by publisher]
Source: Journal of Medical Economics - Category: Health Management Tags: J Med Econ Source Type: research
Condition:   Glaucoma Interventions:   Other: pupillary block group;   Other: plateau iris group;   Other: mixing mechanism group Sponsor:   Zhongshan Ophthalmic Center, Sun Yat-sen University Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
We propose a conceptually simple framework for fast COVID-19 screening in 3D chest CT images. The framework can efficiently predict whether or not a CT scan contains pneumonia while simultaneously identifying pneumonia types between COVID-19 and Interstitial Lung Disease (ILD) caused by other viruses. In the proposed method, two 3D-ResNets are coupled together into a single model for the two above-mentioned tasks via a novel prior-attention strategy. We extend residual learning with the proposed prior-attention mechanism and design a new so-called prior-attention residual learning (PARL) block. The model can be easily buil...
Source: IEE Transactions on Medical Imaging - Category: Biomedical Engineering Source Type: research
Metformin has effective therapeutic effects in anti-tumor and anti-fibrotic diseases. However, how the antifibrotic effect of metformin in the eye and how it is transferred are still unclear. Here, the eye drop of metformin treatment was studied in Sprague–Dawley (SD) rats of glaucoma filtrating surgery (GFS). Rats were administered randomly bilateral drops: control group (without surgery), GFS group, metformin group or mitomycin C (MMC) group (sponge application intraoperatively, 0.02%). Bleb features and intraocular pressure (IOP) were assessed for postoperative week 4. Metformin effectively inhibited fibrosis and ...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
Conclusion: A potential mechanism for IOP reduction in pigmented rabbits is aqueou s humor transport dysfunction due to damage to the nonpigmented epithelial cells of the pars plicata and destruction of basal infoldings. The power of MP-TSCPC was consistent with both morphological changes and IOP reduction.
Source: Ophthalmic Research - Category: Opthalmology Source Type: research
Conclusions: Both ExPRESS mini glaucoma implant and trabeculectomy significantly decreased intraocular pressure and had transient effects on anterior segment parameters, with minor differences between the methods.RESUMO Objetivo: Comparar as altera ções nos parâmetros do segmento anterior após a cirurgia ExPRESS Mini Glaucoma Shunt vs. trabeculectomia usando a câmera Scheimpflug Pentacam rotativa. Métodos: Neste estudo comparativo prospectivo, 27 pacientes com glaucoma tratados no Centro Médico Rabin de 2009 a 2013 foram incluídos nes te estudo comparativo prospectivo: ...
Source: Arquivos Brasileiros de Oftalmologia - Category: Opthalmology Source Type: research
This study evaluated the anti-fibrotic activity of rosmarinic acid on rabbit Tenon ’ s capsule fibroblasts stimulated with transforming growth factor- β 2. Methods: Primary cultures of rabbit Tenon ’ s capsule fibroblasts were treated with various concentrations of rosmarinic acid for 12 h, in the presence and absence of transforming growth factor- β 2. After 48 h, the proliferation index of rabbit Tenon ’ s capsule fibroblasts and the differentiation of myofibroblasts were investigated through immunofluorescence staining for proliferating cell nuclear antigen and alpha smooth muscle actin. An a...
Source: Arquivos Brasileiros de Oftalmologia - Category: Opthalmology Source Type: research
ABSTRACT Purpose: The renin-angiotensin system is involved in the pathogenesis of retinal ischemic conditions and glaucoma. Our objective was to evaluate the renin, angiotensinconverting enzyme 1, and angiotensin-converting enzyme 2 activities in aqueous humor and blood samples of patients with and without primary open-angle glaucoma. Methods: We analyzed samples from 56 participants who underwent ocular surgeries. The patients were divided into two groups: patients with cataract alone (n=28) and patients with cataract and primary open-angle glaucoma (n=28). Venous blood (2 ml) and aqueous humor (150 µl, via paracent...
Source: Arquivos Brasileiros de Oftalmologia - Category: Opthalmology Source Type: research
(University of Maryland School of Medicine) Researchers at the University of Maryland School of Medicine (UMSOM) have for the first time identified stem cells in the region of the optic nerve, which transmits signals from the eye to the brain. The finding, published this week in the journal Proceedings of the National Academy of Sciences (PNAS), presents a new theory on why the most common form of glaucoma may develop and provides potential to treat a leading cause of blindness.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
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