Targeting castration-resistant prostate cancer with a novel RORγ antagonist elaiophylin

Publication date: Available online 12 July 2020Source: Acta Pharmaceutica Sinica BAuthor(s): Jianwei Zheng, Junfeng Wang, Qian Wang, Hongye Zou, Hong Wang, Zhenhua Zhang, Jianghe Chen, Qianqian Wang, Panxia Wang, Yueshan Zhao, Jing Lu, Xiaolei Zhang, Songtao Xiang, Haibin Wang, Jinping Lei, Hong-Wu Chen, Peiqing Liu, Yonghong Liu, Fanghai Han, Junjian Wang
Source: Acta Pharmaceutica Sinica B - Category: Cancer & Oncology Source Type: research

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This study aimed to investigate the stability and therapeutic efficacy of the modified LNA- and PNA-type anti-miRs in a murine prostate cancer model under various treatment conditions. After verifying the anti-cancer potential of anti-miR21 by targeting tumor suppressor PTEN, the potential of the modified LNA- and PNA-type anti-miR21s was compared in vitro and in vivo. We found that PNA-type anti-miR21 showed better stability and therapeutic efficacy in the xenografted mouse tumor model than the LNA-type anti-miR21. Furthermore, PNA-type anti-miR21 treatment showed reduced tumor metastasis. This study may serve a...
Source: Biochemical and Biophysical Research communications - Category: Biochemistry Authors: Tags: Biochem Biophys Res Commun Source Type: research
Abstract Prostate cancer (PCa) is the second leading cause of cancer-associated mortality in men. Speckle-type pox virus and zinc finger protein (SPOP), the most frequently mutated gene in PCa, functions as a tumor suppressor via degradation of cancer-promoting substrates. However, its upstream regulation in PCa metastasis remains poorly determined. Here, in a Snail-induced metastatic PCa model, we observed an accelerated degradation of SPOP protein in cells, which is crucial for the PCa migration and activation of the AKT signaling pathway. Mechanistically, we demonstrated that binding to Snail promoted SPOP ubiq...
Source: Biochemical and Biophysical Research communications - Category: Biochemistry Authors: Tags: Biochem Biophys Res Commun Source Type: research
Patients to be given treatments less likely to damage immune system and in some cases able to be taken at homeNHS England is spending £160m on new “Covid-friendly” cancer drugs that will be less likely to damage the immune system and, in some cases, can be taken at home so that patients do not have to visit hospital.NHS England said 2,000 patients had already benefitted from a range of treatments approved for use as “swaps” for existing drugs. More will be available from this week, after a series of deals struck between the NHS and pharma companies, it said in a statement.Some of these new opt...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: NHS Cancer Society Health Cancer research Medical research Science UK news Coronavirus outbreak Source Type: news
Source: OncoTargets and Therapy - Category: Cancer & Oncology Tags: OncoTargets and Therapy Source Type: research
PROSTATE cancer is the most common cancer in men in the UK, with over 40000 new cases diagnosed every year. Unfortunately, symptoms only show up when the cancer has grown - when this happens, you may encounter a difficulty when going to the toilet.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
CONCLUSION: Every fifth man in the male background population was PSA tested. Repeated PSA testing was common despite low PSA values. As repeated PSA testing was common, especially among older men who will not be included in organized testing, special measures to change the testing patterns in this group may be required. PMID: 32734806 [PubMed - as supplied by publisher]
Source: Scandinavian Journal of Urology - Category: Urology & Nephrology Tags: Scand J Urol Source Type: research
ConclusionAlthough these findings provide some support for a role of adolescent diet in increasing PCa risk, particularly for correlates of milk intake or overall dietary patterns, our protective findings for cheese and ice cream intake with PCa risk and mortality, and for all dairy products with PCa mortality, suggest alternative explanations, such as the influence of early-life socioeconomic status, and increased PCa screening, earlier detection, and better PCa care.
Source: Cancer Causes and Control - Category: Cancer & Oncology Source Type: research
Cancers, Vol. 12, Pages 2141: Quercetin–Resveratrol Combination for Prostate Cancer Management in TRAMP Mice Cancers doi: 10.3390/cancers12082141 Authors: Chandra K. Singh Gagan Chhabra Mary A. Ndiaye Imtiaz A. Siddiqui Jennifer E. Panackal Charlotte A. Mintie Nihal Ahmad Prostate Cancer (PCa) is a leading cause of cancer-related morbidity and mortality in men. Therefore, novel mechanistically-driven approaches are needed for PCa management. Here, we determined the effects of grape antioxidants quercetin and/or resveratrol (60 and 600 mg/kg, respectively, in diet) against PCa in Transgenic Adenoca...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research
Contributors : Brendon M Patierno ; Wen-Chi Foo ; Tyler Allen ; Jason A Somarelli ; Kathryn E Ware ; Santosh Gupta ; Sandra Wise ; John P Wise ; Xiaodi Qin ; Dadong Zhang ; Lingfan Xu ; Yanjing Li ; Xufeng Chen ; Brant A Inman ; Shannon J McCall ; Jiaoti Huang ; Rick A Kittles ; Kouros Owzar ; Simon Gregory ; Andrew J Armstrong ; Daniel J George ; Steven R Patierno ; David S Hsu ; Jennifer A FreedmanSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensHere we report the establishment and characterization of a Prostate Cancer Patient Derived Explant (PCPDX) from a patient of West African an...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
Authors: Saadat M PMID: 32729307 [PubMed - in process]
Source: Polish Journal of Pathology - Category: Pathology Tags: Pol J Pathol Source Type: research
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